Deprecated: Constant E_STRICT is deprecated in /home/websi113/case/germark.com.tw/system/core/Exceptions.php on line 75

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_URI::$config is deprecated

Filename: core/URI.php

Line Number: 101

Backtrace:

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Router::$uri is deprecated

Filename: core/Router.php

Line Number: 127

Backtrace:

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$benchmark is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$hooks is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$config is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$log is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$utf8 is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$uri is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$exceptions is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$router is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$output is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$security is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$input is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$lang is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$db is deprecated

Filename: core/Loader.php

Line Number: 396

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated

Filename: database/DB_driver.php

Line Number: 371

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 132

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 294

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 168

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 237

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 317

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 282

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 289

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 304

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 314

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 315

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 316

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 317

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 375

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 110

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Session cannot be started after headers have already been sent

Filename: Session/Session.php

Line Number: 143

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$session is deprecated

Filename: core/Loader.php

Line Number: 1283

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$pagination is deprecated

Filename: core/Loader.php

Line Number: 1283

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Website_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/Website_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 52
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$Website_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 52
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: News_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter

Filename: models/News_model.php

Line Number: 10

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 53
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/News_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 53
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$News_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 53
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Paper_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter

Filename: models/Paper_model.php

Line Number: 10

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 54
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Paper_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/Paper_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 54
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$Paper_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 54
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Product_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter

Filename: models/Product_model.php

Line Number: 10

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 55
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Product_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/Product_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 55
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$Product_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 55
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

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又一個腸道菌抗癌分子 - Germark Biotechnology 微菌方舟生物科技

微菌新知

又一個腸道菌抗癌分子

2025-05-02  一般

【💬 背景介紹】

✅ 已知產生酯多醣 (lipopolysaccharide,LPS) 的腸道菌會降低免疫療法的療效。

✅ 不同菌會產生不同結構的 LPS,也有不同的免疫刺激效果。

✅ 六醯化 LPS (hexa-acylated LPS) 會活化免疫反應。

✅ 五醯化 (penta-) 和四醯化 (tetra-acylated) LPS 則會拮抗六醯化 LPS 的免疫活化。

 

【💬 研究材料】

✅ 黑色素瘤患者接受 anti-PD1 治療後的糞便 metagenome。

✅ 根據治療結果,可將患者分為有反應者 (Responder,R) 與無反應者 (Non-Responder,NR)。

 

【💬 研究結果】

👀 用 lpxM (六醯化 LPS 合成基因) 數量可以將 R 與 NR 的腸道菌相分開。

👀 lpxM 在黑色素瘤與腎細胞癌患者中都是 R > NR。

👀 Proteobacteria (主要是 Gamma-proteo) 是產生六醯化 LPS 的主要菌種。

 

【🐁 動物實驗】

👀 殺除格蘭氏陰性菌會降低 anti-PD1 免疫療法的效果!

👀 補充六醯化 LPS 可促進 anti-PD1 抑制腫瘤生長!

👀 只補充六醯化 LPS、不給予 anti-PD1 無抑制腫瘤效果。

 

【💡 可能的應用】

🔸 使用六醯化 LPS 搭配免疫療法可能促進腫瘤治療效果!

 

【⚠️ 注意事項】

📝 六醯化 LPS 在血液中 1~4 ng 每公斤體重就會引起發炎反應。

📝 臨床試驗安全性值得評估!

 

發表於 Nat Microbiol (IF 20.5)

原文 https://www.nature.com/articles/s41564-025-01930-y