Deprecated : Constant E_STRICT is deprecated in /home/websi113/case/germark.com.tw/system/core/Exceptions.php on line 75
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Backtrace:
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
Line Number: 127
Backtrace:
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$hooks is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$config is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$log is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$utf8 is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$uri is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$exceptions is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$router is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$output is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$security is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$input is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$lang is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$db is deprecated
Filename: core/Loader.php
Line Number: 396
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
Line Number: 371
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 132
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 294
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 168
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 237
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 317
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 289
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$session is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$pagination is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Website_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Website_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Website_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: News_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/News_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/News_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$News_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Paper_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/Paper_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Paper_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Paper_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Paper_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Product_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/Product_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Product_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Product_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Product_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property ShareMenu_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/ShareMenu_model.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$ShareMenu_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$load is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$languages is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$defaultLang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$perPage is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$benchmark is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$hooks is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$config is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$log is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$utf8 is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$uri is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$exceptions is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$router is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$output is deprecated
Filename: core/Loader.php
Line Number: 931
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維他命D與腸道菌聯手抗癌? - Germark Biotechnology 微菌方舟生物科技
維他命D與腸道菌聯手抗癌?
Group-specific component (Gc) globulin是體內維他命D(VitD)主要的結合蛋白，可調節體內的VitD吸收與利用；如果剔除Gc(-/-)，則可增加腸道中游離的VitD。
實驗發現，Gc(-/-)剔除小鼠身上的腫瘤生長有被顯著抑制；若搭配免疫檢查點抑制劑，Gc(-/-)小鼠更能抑制腫瘤。
接著，WT小鼠無論是(1)與Gc(-/-)剔除小鼠共籠(co-housing)、(2)接受Gc(−/−)剔除小鼠糞便移植，都展現出更強的腫瘤免疫力，證明VitD的效果與腸道菌有關。
機制上，VitD市透過VitD受體(VDR)進行訊息傳遞；下游的shotgun菌相分析發現，VitD會造成B. fragilis(脆弱擬桿菌)的擴張，但會減少P. brevis(普氏菌屬)(兩者皆為常見的共生菌)；在WT小鼠中，補充VitD或管餵Bf菌，都可增強腫瘤免疫力。
在人類資料中發現，癌症患者VitD-VDR下游基因的表現與「存活率的提升」和「免疫治療反應的改善」有關；根據丹麥150萬人的長期追蹤資料，也發現血清VitD濃度低與癌症發病率增加有關，但是不同癌症的效果不一。
發表於 Science. (IF 44.7)
原文 https://www.science.org/doi/10.1126/science.adh7954