Deprecated : Constant E_STRICT is deprecated in /home/websi113/case/germark.com.tw/system/core/Exceptions.php on line 75
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Backtrace:
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
Line Number: 127
Backtrace:
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$hooks is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$config is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$log is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$utf8 is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$uri is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$exceptions is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$router is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$output is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$security is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$input is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$lang is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$db is deprecated
Filename: core/Loader.php
Line Number: 396
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
Line Number: 371
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 132
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 294
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 168
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 237
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 317
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 289
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$session is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$pagination is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Website_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Website_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Website_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: News_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/News_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/News_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$News_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Paper_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/Paper_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Paper_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Paper_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Paper_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Product_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/Product_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Product_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Product_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Product_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property ShareMenu_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/ShareMenu_model.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$ShareMenu_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$load is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$languages is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$defaultLang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$perPage is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$benchmark is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$hooks is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$config is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$log is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$utf8 is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$uri is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$exceptions is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$router is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$output is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$security is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$input is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$lang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$db is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$session is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$pagination is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$Website_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$News_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$Paper_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$Product_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$ShareMenu_model is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
慢性B肝會受到腸道菌的影響 - Germark Biotechnology 微菌方舟生物科技
慢性B肝會受到腸道菌的影響
本篇招募了免疫活躍(immune active)與免疫耐受(immune tolerant)的B肝患者，分析腸道菌相與代謝體，以研究腸道菌對B型肝炎的影響。
相對於免疫活耀(immune active)患者正在經歷清除B肝病毒的過程，免疫耐受的B肝患者體內B肝病毒增殖活躍，但由於宿主免疫系統無法識別病毒抗原而被「耐受」。
研究發現，腸道中的活潑瘤胃球菌(Ruminococcus gnavus，簡稱Rg)與Akk菌(Akkermansia muciniphila，簡稱Akk)的數量在B肝患者腸道中呈現負相關；而根據菌相分析與年齡分組，發現Rg在免疫耐受的年輕患者中(1-12yr)較多，而Akk的出現似乎可以啟動B肝清除的免疫力；動物實驗驗證也證明Rg會延遲B肝病毒清除(HBV clearance)，Akk則會加速清除。
代謝體分析發現，免疫耐受的B肝患者糞便膽固醇與膽酸代謝物高於免疫活躍患者；動物實驗證明，肝臟的膽酸(cholic acid)生成會被Akk給抑制；給小鼠增加攝入膽酸則會減緩B肝病毒清除；實驗結果與病人腸道內Rg與膽酸濃度正相關、Akk與膽酸濃度負相關的觀察吻合。
最後，Akk培養懸浮液(conditional medium，CM)比Akk更能抑制B肝病毒複製，效果來源是因為Akk培養懸浮液可以讓Rg死亡，進一步抑制膽酸的生成與代謝。
發表於 Cell Mol Gastroenterol Hepatol (IF 7.1)
原文 https://www.cmghjournal.org/article/S2352-345X(23)00216-3/fulltext