Deprecated : Constant E_STRICT is deprecated in /home/websi113/case/germark.com.tw/system/core/Exceptions.php on line 75
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_URI::$config is deprecated
Filename: core/URI.php
Line Number: 101
Backtrace:
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_Router::$uri is deprecated
Filename: core/Router.php
Line Number: 127
Backtrace:
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$benchmark is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$hooks is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$config is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$log is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$utf8 is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$uri is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$exceptions is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$router is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$output is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$security is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$input is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$lang is deprecated
Filename: core/Controller.php
Line Number: 82
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$db is deprecated
Filename: core/Loader.php
Line Number: 396
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated
Filename: database/DB_driver.php
Line Number: 371
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 132
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 294
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 168
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 237
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 317
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice
Filename: drivers/Session_files_driver.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 282
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 289
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 304
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 314
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 315
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 316
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 317
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: ini_set(): Session ini settings cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 375
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent
Filename: Session/Session.php
Line Number: 110
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: Warning
Message: session_start(): Session cannot be started after headers have already been sent
Filename: Session/Session.php
Line Number: 143
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$session is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$pagination is deprecated
Filename: core/Loader.php
Line Number: 1283
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Website_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Website_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Website_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: News_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/News_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/News_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$News_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Paper_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/Paper_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Paper_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Paper_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Paper_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Product_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter
Filename: models/Product_model.php
Line Number: 10
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property Product_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/Product_model.php
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$Product_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property ShareMenu_model::$currentLang is deprecated
Filename: core/SelfModel.php
Line Number: 15
Backtrace:
File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
File: /home/websi113/case/germark.com.tw/application/models/ShareMenu_model.php
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property News::$ShareMenu_model is deprecated
Filename: core/Loader.php
Line Number: 358
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$load is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$languages is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$defaultLang is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$perPage is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$benchmark is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$hooks is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$config is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$log is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$utf8 is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$uri is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$exceptions is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$router is deprecated
Filename: core/Loader.php
Line Number: 931
Backtrace:
File: /home/websi113/case/germark.com.tw/application/controllers/News.php
File: /home/websi113/case/germark.com.tw/germark.php
A PHP Error was encountered
Severity: 8192
Message: Creation of dynamic property SelfLoader::$output is deprecated
Filename: core/Loader.php
Line Number: 931
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乳癌治療後會復發嗎? 腸道菌可能已透露線索 - Germark Biotechnology 微菌方舟生物科技
乳癌治療後會復發嗎? 腸道菌可能已透露線索
【💬 背景介紹】
✅ 乳癌發生與雌激素密切相關，而腸道菌中參與雌激素代謝的基因集合 (即 estrobolome) 可影響雌激素循環。
✅ 雖然腸道菌與雌激素會彼此影響，但長期口服內分泌治療 (endocrine therapy；ET) 對腸道菌的影響仍不清楚。
✅ 此外，目前尚未明確釐清腸道菌組成是否與乳癌復發有關。
【💬 研究目標】
📢 評估長期口服內分泌治療對乳癌患者腸道菌的影響，並探討腸道菌組成與復發風險之關聯。
【💬 材料方法】
🧭 共納入 48 位乳癌患者，分為四組：單用 tamoxifen (Tam)、單用 letrozole (Let)、化療合併 letrozole 且未復發 (CLet)、化療合併 letrozole 但復發 (Recu)。
🧭 收集糞便樣本進行 16S rRNA amplicon 定序，以分析腸道菌相。
🧭 同時分析血液 cell-free DNA (cfDNA)，並以腫瘤組織進行 EndoPredict (EPclin) 評分。
🧭 比較不同組別與是否復發之間的菌相差異、多樣性指標與臨床預後。
【💬 主要實驗結果】
💪 長期內分泌治療並未顯著改變整體腸道菌組成。
💪 然而，乳癌復發患者的腸道菌 α-多樣性顯著較低，且 Sutterella 與 Ruminococcus 相對豐度較高。
💪 cfDNA 在不同組別間未呈現顯著差異。
💪 雖然高 EPclin 分數可預測化療獲益，但仍有部分高風險患者發生復發；在這些患者中，腸道菌標誌可有效區分復發與否，且與較差的無惡化存活期 (progression-free survival) 相關，特別是在腫瘤較大的患者中更為明顯。
【💬 研究啟示】
👨🏻🔬 本研究發現在長期內分泌治療下，患者腸道菌可能是影響與預測乳癌復發的重要因素之一。
👨🏻🔬 除了腫瘤基因風險評估 (如 EPclin) 外，腸道菌組成可提供額外的預後資訊。
👨🏻🔬 未來在評估乳癌復發風險時，若能整合宿主基因特徵與腸道菌標誌，可能有助於更精準的個人化治療策略。
【🎉 研究合作說明】
👍 本研究由中中山醫學大學生醫系江誌博老師研究團隊完成，微菌方舟參與其中，主要負責 16S amplicon 資料處理與分析。
發表於 Commun Med (Lond) (IF 6.3)
文章 https://www.nature.com/articles/s43856-026-01384-1