Deprecated: Constant E_STRICT is deprecated in /home/websi113/case/germark.com.tw/system/core/Exceptions.php on line 75

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_URI::$config is deprecated

Filename: core/URI.php

Line Number: 101

Backtrace:

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_Router::$uri is deprecated

Filename: core/Router.php

Line Number: 127

Backtrace:

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$benchmark is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$hooks is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$config is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$log is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$utf8 is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$uri is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$exceptions is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$router is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$output is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$security is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$input is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$lang is deprecated

Filename: core/Controller.php

Line Number: 82

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$db is deprecated

Filename: core/Loader.php

Line Number: 396

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property CI_DB_mysqli_driver::$failover is deprecated

Filename: database/DB_driver.php

Line Number: 371

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::open($save_path, $name) should either be compatible with SessionHandlerInterface::open(string $path, string $name): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 132

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::close() should either be compatible with SessionHandlerInterface::close(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 294

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::read($session_id) should either be compatible with SessionHandlerInterface::read(string $id): string|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 168

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::write($session_id, $session_data) should either be compatible with SessionHandlerInterface::write(string $id, string $data): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 237

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::destroy($session_id) should either be compatible with SessionHandlerInterface::destroy(string $id): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 317

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Return type of CI_Session_files_driver::gc($maxlifetime) should either be compatible with SessionHandlerInterface::gc(int $max_lifetime): int|false, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice

Filename: drivers/Session_files_driver.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 282

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_set_cookie_params(): Session cookie parameters cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 289

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 304

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 314

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 315

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 316

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 317

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: ini_set(): Session ini settings cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 375

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_set_save_handler(): Session save handler cannot be changed after headers have already been sent

Filename: Session/Session.php

Line Number: 110

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Session cannot be started after headers have already been sent

Filename: Session/Session.php

Line Number: 143

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$session is deprecated

Filename: core/Loader.php

Line Number: 1283

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$pagination is deprecated

Filename: core/Loader.php

Line Number: 1283

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 17
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Website_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/Website_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 52
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$Website_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 52
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: News_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter

Filename: models/News_model.php

Line Number: 10

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 53
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/News_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 53
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$News_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 53
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Paper_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter

Filename: models/Paper_model.php

Line Number: 10

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 54
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Paper_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/Paper_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 54
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$Paper_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 54
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Product_model::getList(): Optional parameter $search declared before required parameter $perPage is implicitly treated as a required parameter

Filename: models/Product_model.php

Line Number: 10

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 55
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property Product_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/Product_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 55
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$Product_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfController.php
Line: 55
Function: model

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 10
Function: __construct

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property ShareMenu_model::$currentLang is deprecated

Filename: core/SelfModel.php

Line Number: 15

Backtrace:

File: /home/websi113/case/germark.com.tw/application/core/SelfModel.php
Line: 15
Function: _error_handler

File: /home/websi113/case/germark.com.tw/application/models/ShareMenu_model.php
Line: 7
Function: __construct

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 12
Function: model

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property News::$ShareMenu_model is deprecated

Filename: core/Loader.php

Line Number: 358

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 12
Function: model

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$load is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$languages is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$defaultLang is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$perPage is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$benchmark is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$hooks is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$config is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$log is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$utf8 is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$uri is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$exceptions is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$router is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$output is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$security is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$input is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$lang is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$db is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$session is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$pagination is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$Website_model is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$News_model is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$Paper_model is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$Product_model is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

A PHP Error was encountered

Severity: 8192

Message: Creation of dynamic property SelfLoader::$ShareMenu_model is deprecated

Filename: core/Loader.php

Line Number: 931

Backtrace:

File: /home/websi113/case/germark.com.tw/application/controllers/News.php
Line: 69
Function: view

File: /home/websi113/case/germark.com.tw/germark.php
Line: 320
Function: require_once

有效無效? 癌症治療特徵菌群可能取決於免疫療法 - Germark Biotechnology 微菌方舟生物科技

微菌新知

有效無效? 癌症治療特徵菌群可能取決於免疫療法

2024-09-27  一般

本研究招募了三種罕見癌症、共106位病患，接受了兩種免疫檢查點抑制劑的組合治療(combined immune checkpoint blockade，CICB)，透過治療前的基礎腸道菌相(baseline)，分析腸道菌相與免疫療法可能的關聯性。

若以最佳治療效果(best overall response，BOR)來分組，基礎腸道菌相多樣性越高、血中albumin濃度都正比治療效果。

用菌相來預測response/remission(R)、progression(P)，則以strain效果最好；其中有找到7株潛在可能幫助治療的好菌，都具備完整的丁酸生成路徑(pathway)。

以已發表的資料來驗證，發現同樣是組合免疫療法(CICB)的菌相資料效果較好，但是單一療法的菌相資料則驗證效果較差，說明免疫療法的策略(組合或單一)是影響特徵菌相的另一個關鍵。

發表於 Nat Med (IF 87.241)

原文 https://www.nature.com/articles/s41591-024-02823-z